Abstract: “The acid-base equilibria of polyvinyl alcohol(PVA) is investigated. The stability constant values of the binary and ternary complexes formed in solution between polyvinyl alcohol, Cu(II), some amino acids and DNA were determined potentiomertically. The stability constants of the complexes are determined and the concentration distribution diagrams of the complexes are evaluated. The ligand and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria and fungi. Binary and ternary complexes of copper(II) involving polyvinyl alcohol(PVA) and various biologically relevant ligands containing different functional groups, were investigated. The ligands (L) are amino acids and DNA constituents. The ternary complexes of amino acids and DNA are formed by simultaneous and stepwise processes respectively. The results showed the formation of Cu(PVA)(L) complexes with amino acids and DNA. Amino acids form both Cu(PVA)(L)”

Keywords: Copper(II), Amino acids, DNA constituents, Stability constant, Spectroscopic characterization, Biological activity