Abstract: “E-learning should be pedagogically-driven rather than technologically-driven. Technology that is applied in conjunction with pedagogical concepts can create an effective student-centered environment and enhance learning outcomes. The objective of this study is to develop an interactive multimedia in order to achieve the intended learning outcomes and to enhance self-regulated learning. An interactive multimedia on bright-field microscopy technique was developed in the CD-ROM which included various elements; text, images, animations, video, and audio. We conducted an experiment with thirty first-year biomedicine students in Universiti Sains Malaysia attended a 3-hour fixed laboratory session for conventional teaching and learning for bright-field microscopy technique. At the end of the session, all students were given the first set of questionnaires. After the conventional lab session, the same students were provided with multimedia teaching and learning materials and then were given th”

Keywords: e-learning, educational technology, interactive multimedia, teaching and learning, bright-field micr