Abstract: “Cerebrovascular disease risk including stroke is projected as the second most frequent cause for death/disability by year 2020. Preventive measures tominimize stroke related hippocampal cognitive impairmentin high risk group gains least attention among health-care professionals. Several studies establish the critical importance of essential dietary components choline and Docosahexaenoic acid [DHA] as neuronal membrane phospholipid precursors that maintain cognitive states in health and in neurological disorders. There are no studies exploring the synergetic neuro-protective potential of choline and DHA in attenuating hippocampal neural deficits in stroke-risk group. The present study explores synergetic neuro-protective potential of choline and DHA supplemented to Wistar rats prior to hypo-perfusion ischemic brain injury. 10 month-old male Wistar rats were subdivided into 4 groups [n=8 /group]-Normal control group [NC], Bilateral common carotid artery occlusion group [BCCAO], Sham BCCA”

Keywords: Chronic cerebral hypoperfusion brain injury, Combined Choline-DHA therapy, Hippocampal neural cells, synergetic neuroprotection