Abstract: “The remarkable ability of Pseudomonas aeruginosa to adapt and thrive in wide variety of environments is due in part to its extensive genetic versatility, which contributes significantly to its potential pathogenicity. Depending on the environmental conditions and the immune status of the host, P.aeruginosa can be a quiescent colonizer, a case of chronic infections, or highly virulent invader during acute infections. The study is to assess the antibacterial effect of a new special solution made by a mixture of sidr infusion (Ziziphussspina- Christi (L) var. inermisBoiss) with Hydrogen peroxide. In this study, P.aeruginosa isolates exhibited high resistance rate toward Cefataxime (CTX:30mg), Ceftazidme (Ca:30mg). Gentamicin (CN: 10 mg) and Carbenicillin (Py: 100mg). while Norfloxacin (NOR:10mg), Tobramycin (TOB:10mg) and Amikacin (Ami:30 mg) inbition zone of sensitive isolate in disc diffusion test were determined at (22.16 and 20) mm respectively. We was tested their decontamination usi”

Keywords: Sidr infusion, Hydrogen peroxide, special antibacterial, P.aeruginosa.