Abstract: “Antibiotic resistance in clinically important bacteria is an increasing problem worldwide. Alternative therapeutic agents such as medicinal plants should be sourced to overcome this problem. Acne is a common skin disorders in many people and can have a debilitating effect on the self-esteem and confidence of an individual. Staphylococcus aureus and Staphylococcus epidermidis. The aim of this study was to determine if crude plant extracts from medicinal plants could be used as a suitable alternative to antibiotics for the treatment of acne. Crude extracts were obtained from three medicinal plants: Plectrantus amboinicus, Azadirachta indica and Murraya koenigii using an ethanol extraction method. The extracts were tested individually and in combination against two common causative agents of acne: Staphylococcus aureus and Staphylococcus epidermidis. The antimicrobial activity was indicated by the zone of inhibition obtained in the disk diffusion assay. All the plant extracts exhibited an”

Keywords: plant extracts, Staphylococcus aureus, Staphylococcus epidermidis, acne, antimicrobial properties