EVALUATION OF ABERRANT P16INK4Α PROMOTER CPG METHYLATION AND ITS APPLICATION IN VIETNAMESE BREAST CANCERS PATIENTS
Published In: 4TH INTERNATIONAL CONFERENCE ON ADVANCES IN APPLIED SCIENCE AND ENVIRONMENTAL ENGINEERING
Author(s): LE HUYEN AI THUY , TRUONG KIM PHUONG , DOAN THI PHUONG THAO , LAO DUC THUAN
Abstract: The disruption of genetic materials as the aberrant methylation at CpG islands of tumor suppressor gene’s promoter, which is thought to be a driver epigenetic events of malignant cells. p16INK4α, its function is considered as an inhibitor of CDK4 and CDK6 that initiate the phosphorylation of RB (retinoblastoma tumor suppressor protein), has been identified as a tumor suppressor gene in many human cancers. In current study, methylation specific PCR (MSP) was carried out to evaluate the methylation status of p16INK4α from Vietnamese breast patients, in order to find out the methylation signature served as biomarker applied in prognosis, early detection and diagnosis of breast cancer in Vietnamese population. The results showed that the methylation frequency of p16INK4α promoter reached to 49.5% (47 of 95 breast cancer samples). In the case of non-cancer specimens, only 15% (3 of 20 non-cancer specimens) was methylation. According to clinical parameters, there were significant correlation
- Publication Date: 27-Sep-2015
- DOI: 10.15224/978-1-63248-068-2-10
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A PRESSURE DEPENDENT ANALYSIS-BASED INDEX TO ASSESS RELIABILITY OF WATER DISTRIBUTION NETWORKS
Published In: 4TH INTERNATIONAL CONFERENCE ON ADVANCES IN APPLIED SCIENCE AND ENVIRONMENTAL ENGINEERING
Author(s): AKBAR SHIRZAD , MASSOUD TABESH
Abstract: Reliability of Water Distribution Networks (WDNs) is one of the most important issues in planning and management of these networks. In the previous studies various indices have been proposed to evaluate the reliability of WDNs. These indices which have some advantages and disadvantages can also be an indicator for efficiency of WDNs. Since the Pressure Dependent Analysis (PDA) of WDNs has more accurate results than the Demand Dependent Analysis (DDA), then in this study a new index is proposed for reliability assessment of WDNs based on PDA. According to this index, the nodal pressures and the nodal available demands are the most factors influencing the reliability of WDNs. A sample network is also used to compare the new proposed index and the available indices and their efficiencies in assessing the reliability of WDNs
- Publication Date: 27-Sep-2015
- DOI: 10.15224/978-1-63248-068-2-57
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