MOLECULAR MODELING STUDIES FOR EXPLORING STRUCTURAL REQUIREMENT OF ACETYLCHOLINESTERASE INHIBITORS
Published In: 4TH INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS AND ENVIRONMENTAL ENGINEERING
Author(s): ACHINTYA SAHA , TABASSUM HOSSAIN
Abstract: Inhibition of the neurotransmitter acetylcholine (ACh) can control the alzheimer’s disease (AD). The ACh hydrolyzes to produce choline and acetyl groups through acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in the synaptic region, which play a key role in accelerating senile amyloid β-peptide (Aβ) plaque depositions, leads to generation of AD. The present study has been emphasized to explore both ligand- and structure-based QSAR and docking studies on a set of structurally diverse compounds to explore prime structural features responsible for selective binding to AChE, vis–a-vis inhibiting enzyme activity. Both the studies showed the importance of HB acceptor and donor, and hydrophobic features of the molecule for effective binding. Systematic comparisons revealed that structure-based study has advantages in efficiently identifying potent hits with structural diversity over simple ligand-based study. Structure-based QSAR study (site score = 1.006) adjudged the significan
- Publication Date: 19-Aug-2016
- DOI: 10.15224/978-1-63248-100-9-17
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STUDY ON MASONRY BLOCKS FABRICATED FROM WASTE PAPER AND INDUSTRIAL WASTE SPENT CATALYST
Published In: 4TH INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS AND ENVIRONMENTAL ENGINEERING
Author(s): ADNAN M NIDAL SHMS EDDIN , SANJAY GOVIND PATIL , TALAL MOHAMMED SULTAN AL SHIBANI
Abstract: Disposal of industrial waste is a major concern all over the world due to stringent laws enforced by government agencies. This has motivated many researchers to recycle these wastes into an innovative construction material. Presently, these wastes are recycled to some extent, however the majority of them disposed to landfill. Thus, leading to environmental issues. Similarly, industrial waste, such as spent catalyst and waste papers are hardly recycled in Oman. The present paper discusses the study carried out on Masonry Blocks (MB) fabricated using spent catalyst, lime and waste paper sludge. MB-1 block consists of lime and waste paper sludge as filler material, whereas spent catalyst and waste paper sludge is used in the MB-2 block. For both masonry bocks ordinary Portland cement is used as binder. Laboratory investigation carried out in the material testing laboratory at Caledonian College of Engineering in terms of compressive strength, creep, alternate wetting and drying and therma
- Publication Date: 19-Aug-2016
- DOI: 10.15224/978-1-63248-100-9-19
- Views: 0
- Downloads: 0