OPEN SOURCE DRUG DISCOVERY FOR CHIKUNGUNYA
Published In: INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS, BIO-TECHNOLOGY AND ENVIRONMENTAL ENGINEERING
Author(s): CHETANA SHETTY , DEEPA MOHAN , MAYURI RANE , PADMAVATHI P , SANDHYA S
Abstract: Chikungunya is viral disease is transmitted to human beings by mosquito bite [2]. Chikungunya can cause fever, chills, nausea, vomiting, joint pain, head ache, and swollen in the joints. A cause of Chikungunya is mainly due to the replication of Chikungunya virus in the human body [5]. The protein E1 was used in the study which is monomer with molecular weight 50KDa which is anchored in the membrane of CHIKV. The structure of E1 was retrieved from Protein Data Bank. The PDB ID for E1 was 3N41 , which is responsible for Chikungunya virus replication. CHIKV replication is resistant to inhibition by interferon once RNA replication has been established and that CHIKV actively suppress the antiviral IFN response by preventing IFN-induced gene expression there by making host to shut-off [4,2].The report have shown that the intensity of the infection has increased with every passing year with 45%–63% attack rates in world during outbreaks India is endemic to dengue fever and due to overlappin
- Publication Date: 02-Jun-2014
- DOI: 10.15224/978-1-63248-009-5-95
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BEADS THE INDIAN SPECIFIC MUTATION DATABASE
Published In: INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS, BIO-TECHNOLOGY AND ENVIRONMENTAL ENGINEERING
Author(s): ARCHANA V PAWAR , MANASA D A , RESHMA MANE , SUKANYA V K , VIDYA NIRANJAN
Abstract: India is a country with incredible, biological and cultural diversity. Its natural resources attracted to the subcontinent many streams of people at different times, from different directions. This migration brought out a great diversity in human genes and cultures, resulting in a racial admixture of the Indian population. However, till date no database accounting for genetic mutations, abnormalities and variants of genetic diseases specific to the Indian population has been created. We have designed an Indian specific mutation database – BEADS based on SQL and JAVA. It’s easy-to-use web interface will allow a remote user to retrieve (and submit) data on patient-specific mutation spectrum of genetic diseases through interactive web forms. The database will be helpful to the Physicians, Geneticists and other professionals in India as it provides information about the specific mutations pertaining to the Indian population. It will also provide links to other major public databases based
- Publication Date: 02-Jun-2014
- DOI: 10.15224/978-1-63248-009-5-96
- Views: 0
- Downloads: 0