DEVELOPMENT AND OPTIMIZATION OF INTEGRATED PIPELINES FOR PHYLOGENY AND EVOLUTIONARY ANALYSES
Published In: INTERNATIONAL CONFERENCE ON ADVANCES IN ENVIRONMENTAL AND BIO-TECHNOLOGY
Author(s): GUOQING LU , SANTOSH SERVISETTI , ZHENGXIN CHEN
Abstract: Recently development of automated and integrated pipelines for phylogeny and evolutionary analyses has received a lot of attention. In this paper, we describe our approach of pipeline development. Our design focuses on integration, not only in the integrated result (i.e., the pipelines), but also in the integrated approach in the design process, so that we can exploit all kinds of resources available to us. In addition, we want integrated pipelines not only work effectively, but also efficiently. In this paper, we describe our two-step design: A basic approach and an optimized approach which takes advantage of parallelism offered by supercomputers. We present the major phases of pipeline development, describe methods used in optimization(including the sequence-split-logic), show the experimental result, and compare it with non-optimized implementation.
- Publication Date: 05-Jan-2014
- DOI: 10.15224/978-981-07-8859-9-77
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DESIGN AND FABRICATION OF POLYMERIC THINFILM AND ULTRA THIN FILM SENSOR CHIP FOR BIOMOLECULES CAPTURING BY SURFACE PLASMON RESONANCE TECHNIQUE
Published In: INTERNATIONAL CONFERENCE ON ADVANCES IN ENVIRONMENTAL AND BIO-TECHNOLOGY
Author(s): THIDARAT WANGKAM , TOEMSAK SRIKHIRIN
Abstract: Development of sensor chip to be high specificity and fitted in each application is important. This work, we designed and fabricated the sensor chips to be model of biomedical chip in form of polymethyl metacrylate(PMMA) thin film and Self-assembled monolayer (SAM) thin film which were coated on gold substrate with physisorption and chemisorption method, respectively. The detection of bimolecular interaction such as protein and collagen were tested by Surface Plasmon resonance (SPR) technique. SPR is an optical technique, which is highly sensitive on the change of the optical properties of the biomolecules in nanoscale. Thesuitable condition for protein and collagen adsorption on these two thin film were studied. It was found that the different types of surfaces on various pH condition has effect on the biomolecule adsorption. The fabricated sensor chips can be used to be the model chip for bimolecular capturing and capable to develop in medical application further.
- Publication Date: 05-Jan-2014
- DOI: 10.15224/978-981-07-8859-9-78
- Views: 0
- Downloads: 0