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GENO- AND CYTOTOXICOLOGIC ASSESSMENT OF WASTEWATER EFFLUENTS WITH MUSSEL MICRONUCLEUS ASSAY AND WITH FLOW CYTOMETRIC SPERM TOXICITY ASSAY: A COMPARISON.

Published In: 3RD INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS AND ENVIRONMENTAL ENGINEERING
Author(s): BETTINA ECK-VARANK , GABOR PAULOVITS , NORA KOVATS , BALAZS KAKASI , SZABOLCS TAMAS NAGY

Abstract: Several pharmaceutical drugs have potential harmful effect on wildlife such as aquatic toxicity, genotoxicity, or endocrine disruption effect. Removal rates of pharmaceuticals from municipal sewage during waste water treatment is questionable, several studied drugs are insufficiently or not removed while passing through the sewage treatment plants (STP).The analytical monitoring of potentially harmful drugs and especially drug residues in influent and effluent of STP are rather costly and not always possible on a day to day basis. Toxicity bioassays, on the other hand, are relatively cost-effective short-term tests, estimating the aggregate genotoxicity of the samples on different taxonomic levels. In our study the cyto- and genotoxicity of the pre-treated potentially pharmaceutical containing influent and the effluent sample of a Hungarian STP were estimated with mussel (Unio pictorum) micronucleus (MN) assay and flow cytometric boar spermatozoa assay. The influent induced in the flow

  • Publication Date: 11-Dec-2015
  • DOI: 10.15224/978-1-63248-078-1-70
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ASSESSMENT OF MUNICIPAL WASTEWATER GENOTOXICITY USING THE AMES FLUCTUATION TEST, THE SOS CHROMOTEST AND THE MUSSEL MICRONUCLEUS TEST: A COMPARISON

Published In: 3RD INTERNATIONAL CONFERENCE ON ADVANCES IN BIO-INFORMATICS AND ENVIRONMENTAL ENGINEERING
Author(s): BETTINA ECK-VARANK , ESZTER HORVATH , GABOR PAULOVITS , NORA KOVATS

Abstract: Municipal wastewaters may contain a variety of genotoxic compounds, including drugs or their metabolites, PAHs, etc. Bacterial genotoxicity assays use DNA impairment as end point while micronucleus tests, conducted on eucaryotes, assess chromosome aberrations. As relatively few comparative studies exist, in this study results of the micronucleus test using the painter’s mussel (Unio pictorum) are compared to those of two bacterial assays, the Ames test and the SOS Chromotest. Both the Ames test and the micronucleus test showed clear concentration-response pattern, however, the Ames test proved more sensitive. Of the two bacterial assays, the SOS Chromotest gave positive result only for the most concentrated sample.

  • Publication Date: 11-Dec-2015
  • DOI: 10.15224/978-1-63248-078-1-69
  • Views: 0
  • Downloads: 0